The Biggest Contribution Of Sports Card Shows To Humanity | sports card shows

The Biggest Contribution Of Sports Card Shows To Humanity | sports card shows

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Houston Astros brilliant Alex Bregman took Major League Baseball by storm in 2018. Not alone did he accept an MVP-caliber year, but his personality was on abounding affectation during Houston’s AL West-winning season, authoritative him one of the best adolescent players to watch in the bold — for added than one reason.

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One affair you’ll apprentice in this week’s cast new adventure of “Old Baseball Cards,” our baseball-card apprenticed homesickness appearance actuality on Beast Sports, is that Bregman additionally has a advantageous account for the history of the game. We were activity to do article altered on this week’s appearance and accessible some new accepted baseball cards with a accepted brilliant of the game. But Bregman capital to dip aback into 1999.

So you’ll acquisition us aperture 1999 Fleer Ultra and some 2018 Topps Archives, which has some earlier players alloyed with new. Along the way, we allocution about greats like Cal Ripken Jr. and Rickey Henderson, additional accepted players like Evan Longoria and Carson Fulmer. Our best acquisition is Mark McGwire, who Bregman dressed up as for Halloween eight years in a row, he says. It’s a fun adventure with a fun player.

Alex Bregman talks about his acquaintance Carson Fulmer on “Old Baseball Cards.” (Yahoo Sports)

If you’re new to our series, we accessible old packs of cards with players, coaches and acclaimed fans. It’s generally with the greats of the game, but we’re blessed to affection some of MLB’s adolescent claret in this episode. We’re not attractive for cool admired cards on “Old Baseball Cards” — but that would be abundant — we’re absolutely attractive for abundant stories, memories and reactions.

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If you dig this episode, I’d acclaim you additionally analysis out our eps with CC Sabathia, Curtis Granderson and A.J. Ellis.

Previously on Old Baseball CardsMUST-SEE EPISODES: David Ross | Dave Winfield | Tim Raines | Thomas Ian Nicholas aka Henry Rowengartner | Mike Krukow | Gary Vee | Randy Johnson | Felipe Alou | George Brett | Torey Lovullo | Pedro Martinez | Bronson Arroyo | Eric Davis | Dusty Baker | Hank Azaria | Alex Rodriguez | Scott Boras | A.J. Ellis | Bernie Williams | Chase Utley | John Smoltz | Best trades of 2017 | Best finds of 2017 | Best Guests of 2017 (Part 1) | Best Guests of 2017 (Part 2)

CROSSOVER EPISODES: The Miz | Metta World Peace | Jazzy Jeff

STARS FROM BACK IN THE DAY: Fred Lynn | Eduardo Perez | J.J. Putz | Luis Gonzalez | Duane Kuiper | Edgar Martinez | Ryne Sandberg | Frank Thomas | Sandy Alomar Jr. | Delino DeShields | Cliff Floyd | Dan Plesac | Aaron Boone | Bobby Bonilla | Andre Dawson | Ivan Rodriguez | Jack Morris | Jeff Nelson | Mark Teixeira | Rick Ankiel | Kevin Millar

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MANAGERS/COACHES: Terry Francona | Joe Maddon | Bruce Bochy | Clint Hurdle | Buck Showalter | Brad Mills | Bob Melvin | Dave Roberts | Gabe Kapler | Alex Cora | Dave Martinez | Ron Gardenhire | Scott Servais

CURRENT PLAYERS: CC Sabathia | Curtis Granderson | Noah Syndergaard | Kyle Hendricks | Clayton Kershaw | Todd Coffey | John Axford | Dee Gordon | Adam Eaton | Rajai Davis | Brad Ziegler & Tyler Clippard | Buster Posey, David Price & Anthony Rizzo

CELEBS: Kurt Busch | Bill Nye | HQ’s Scott Rogowsky | Mr. Belding | Alyssa Milano | Josh Duhamel | Joel McHale

ETC: Chris “Mad Dog” Russo | Josh Kusnick | Jeff Passan | Ken Kendrick

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– – – – – –

Mike Oz is a biographer at Beast Sports. Contact him at mikeozstew@yahoo.com or chase him on Twitter!

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Noninvasive Test for Colon Cancer Shows Promise in Early Trial

Noninvasive Test for Colon Cancer Shows Promise in Early Trial

Noninvasive Test for Colon Cancer Shows Promise in Early Trial

Stool-based screen beats current versions, but results must be replicated in larger trials, experts say

A new noninvasive test to detect pre-cancerous polyps and colon tumors appears to be more accurate than current noninvasive tests such as the fecal occult blood test, Mayo clinic researchers say.

The search for a highly accurate, noninvasive alternative to invasive screens such as colonoscopy or sigmoidoscopy is a “Holy Grail” of colon cancer research.

In a preliminary trial, the new test was able to identify 64 percent of pre-cancerous polyps and 85 percent of full-blown cancers, the researchers reported.

Dr. Floriano Marchetti, an assistant professor of clinical surgery in the division of colon and rectal surgery at University of Miami Sylvester Comprehensive Cancer Center, said the new test could be an important adjunct to colon cancer screening if it proves itself in further study.

“Obviously, these findings need to be replicated on a larger scale,” he said. “Hopefully, this is a good start for a more reliable test.”

Dr. Durado Brooks, director of colorectal cancer at the American Cancer Society, agreed. “These findings are interesting,” he said. “They will be more interesting if we ever get this kind of data in a screening population.”

The study’s lead researcher remained optimistic.

“There are 150,000 new cases of colon cancer each year in the United States, treated at an estimated cost of $ 14 billion,” noted Dr. David A. Ahlquist, professor of medicine and a consultant in gastroenterology at the Mayo Clinic in Rochester, Minn.

“The dream is to eradicate colon cancer altogether and the most realistic approach to getting there is screening,” he said. “And screening not only in a way that  would not only detect cancer, but pre-cancer. Our test takes us closer to that dream.”

Ahlquist was scheduled to present the findings of the study Thursday in Philadelphia at a meeting on colorectal cancer sponsored by the American Association for Cancer Research.

The new technology, called the Cologuard sDNA test, works by identifying specific altered DNA in cells shed by pre-cancerous or cancerous polyps into the patient’s stool.

If a DNA abnormality is found, a colonoscopy would still be needed to confirm the results, just as happens now after a positive fecal occult blood test (FOBT) result.

To see whether the test was effective, Ahlquist’s team tried it out on more than 1,100 frozen stool samples from patients with and without colorectal cancer.

The test was able to detect 85.3 percent of colorectal cancers and 63.8 percent of polyps bigger than 1 centimeter. Polyps this size are considered pre-cancers and most likely to progress to cancer, Ahlquist said.

The sensitivity of the test is much better than what has been seen in other stool screening tests, the ACS’ Brooks added. “But, showing that in a small group of samples is very different from demonstrating that in a population where only a small number of individuals are going to have polyps of that size. Then we will know if this is a big step forward,” he said.

According to Ahlquist, Cologuard is the first noninvasive test to detect pre-cancerous polyps, he added.

In addition, the test is the only one that is able to identify cancer in all locations throughout the colon, something which other tests either can’t or don’t do well, Ahlquist said.

One more advantage: patients do not need to do any special preparation before taking the test, something that other tests require, he added.

Ahlquist noted that the test still needs to be refined. “We learned there are still some bugs and we can make the test even better,” he said.

Cologuard is not yet available for sale. Clinical trials comparing the test with colonoscopy are slated to start next year. Ahlquist hopes that the test will be approved and available within two years.

Ahlquist noted that the cost of the test has not yet been established. It is expected to cost more than a fecal occult blood test, but far less than a colonoscopy. A fecal occult blood test can cost as little as $ 23 while a colonoscopy can total $ 700.

Another benefit is that it would probably need to be done once every three years; while the fecal occult blood test is usually done yearly. Savings over time on a more accurate test done fewer times could justify the higher cost of the Cologuard test, Ahlquist said.

In two other presentations at the meeting, researchers have linked key gene variants to the risk for colon cancer and also to the prognosis of the disease.

In one study, researchers found that people who have long telomeres, the small strips of DNA that cover the ends of chromosomes, have a 30 percent increased risk of developing colon cancer.

“Even for people their age, their telomeres were longer than you’d expect for healthy people,” lead researcher Dr. Lisa A. Boardman, an associate professor of medicine at the Mayo Clinic, said in a statement. “This suggests that there may be two different mechanisms that affect telomere length and that set up susceptibility to cancer,” she said.

In the other study, a research team led by Kim M. Smits, a molecular biologist and epidemiologist in the GROW-School for Oncology and Developmental Biology at Maastricht University Medical Center in the Netherlands, uncovered a surprise when it came to a gene variant on the KRAS gene called the G variant. This variant, long linked to poorer outcomes in advanced colorectal cancer, actually predicted a better prognosis in early-stage colon cancer.

“You would intuitively think that the G variant would be associated with a poorer prognosis, as it is in late-stage colorectal cancer, but that is not the case,” Smits said in a statement.

Experts point out that studies presented at scientific meetings do not have to pass the rigorous peer review of studies published in reputable journals.

SOURCES: David A. Ahlquist, M.D., professor of medicine, Mayo Clinic, Rochester, Minn.; Durado Brooks, MD, director of colorectal cancer,American Cancer Society; Floriano Marchetti, M.D., assistant professor of clinical surgery, Division of Colon and Rectal Surgery, University of Miami Sylvester Comprehensive Cancer Center; Oct. 28, 2010, presentation, 2010 Special Conference for Colorectal Cancer: Biology, American Association for Cancer Research, Philadelphia

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